In the human body there are two types of fat – a conditionally useful “brown” and harmful “white”, which so easily accumulates on the abdomen and thighs. At Purdue University, they developed a drug to convert one type of fat to another, and to achieve the best effect, they want to inject the drug point-wise, as injections from nanoparticles. Several sessions of injections – and the body itself will begin to fight obesity.
The mechanism of converting white fat to brown is based on blocking the signal system that exists between the adipose tissue cells. Fat cells are able to influence the genes of neighbors and turn them into their similarity, and the white fat clearly dominates the brown. But if you block this connection, its distribution will stop. And instead of deposition of useless fat in the body, we will accumulate the necessary reserves of energy substances.
Blocking of intercellular bonds causes the drug Dibenzazepine, which scientists suggest to pack into tiny capsules with a diameter of 200 nanometers with a polymer shell. It dissolves slowly enough, therefore all substance will be absorbed only by nearby cells and will not extend on an organism. Instead of taking tablets and potions, one injection is made to the target area – over time, the white fat in it will be replaced by a brown one.
Experiments on fattened mice showed that the idea is more than workable, and in addition to reducing fat in animals reduces the risk of diabetes and other diseases associated with obesity. Plans to use injections of nanoparticles in humans have not yet been announced, but the technology is workable and is not at all fiction.
Details of this study were published in the journal Molecular Therapy.